Author

Marta Guevara‐Ferrer

Hospital for Sick ChildrenORCID 0000-0002-5334-3344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

James EllisiD· 2 shared Wei WeiiD· 2 shared Alejandro GarantoiD· 1 shared Alina Piekna· 1 shared Amalia M. DolgaiD· 1 shared Ángeles AlmeidaiD· 1 shared Anita Lygeroudi· 1 shared Annika MordeltiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

James EllisORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network development

Imke M. E. Schuurmans, Annika Mordelt, Marta Guevara‐Ferrer, Katrin Linda, Denise Joanne Duineveld, Sofía Puvogel, Marina P. Hommersom, Nicky Scheefhals, Lisa Rahm, Emma Dyke, Gijs-Jan Scholten, Caroline Knorz, Carlos O. González Jiménez, Noëlle van Egmond, Astrid R. Oudakker, , Nael Nadif Kasri

This study presents a one-step protocol to differentiate hiPSCs into functional astrocytes, enabling co-culture with neurons to support network development.

Pure Amsterdam UMC · Sep 1, 2026Peer-reviewedNeuroscience

Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism

Fraser P. McCready, Kartik S. Pradeepan, Milad Khaki, Wei Wei, Marta Guevara‐Ferrer, Nicole Matusiak, Britney Feng, Alina Piekna, Julio Martínez-Trujillo, James Ellis

This study shows that SHANK2 variants cause hypersynchronous neuronal network activity in human iPSC-derived neurons, which is rescued by mGluR5 agonism.

Stem Cell Reports · Nov 20, 2025Peer-reviewedNeuroscience

Mitochondrial collapse links PFKFB3-promoted glycolysis with CLN7/MFSD8 neuronal ceroid lipofuscinosis pathogenesis

Irene López-Fabuel, Marina García Macia, Costantina Buondelmonte, Olga Burmistrova, Nicoló Bonora, Brenda Morant-Ferrando, Paula Alonso-Batan, Carlos Vicente‐Gutiérrez, Daniel Jiménez-Blasco, Rubén Quintana–Cabrera, Emilio Fernández, Aseel M. Sharaireh, Marta Guevara‐Ferrer, Lorna M. FitzPatrick, Christopher D. Thompton, , Juan Pedro Bolaños

This study identifies a metabolic shift driven by PFKFB3 in CLN7 disease, showing that targeting glycolysis can alleviate disease hallmarks in a mouse model and patient-derived cells.

bioRxiv · Oct 20, 2020 · PreprintNeuroscience