Author

Levan Mekerishvili

New York Genome CenterORCID 0000-0002-4792-5356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Dan Avi LandauiD· 3 shared Clifford ChaoiD· 2 shared Dan HassoniD· 2 shared Elvin WagenblastiD· 2 shared Franco IzzoiD· 2 shared Grace S. FreediD· 2 shared Isabella G. MartineziD· 2 shared Ivan RaimondiiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenomics

Dan Avi LandauORCID

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Author profile →

4 papers

Recent·Most cited

A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression

Grace S. Freed, Miguel Quijada Álamo, L Lee, Ke Wang, Nikita Poddar, Subrina Persaud, Saul Carcamo, Persephone Fiore, Emma K Kim, Isabella G. Martinez, Mimi Zhang, Shayan Saniei, Clifford Chao, Levan Mekerishvili, Zayna Diaz, , Elvin Wagenblast

This paper uses a CRISPR-based humanized model to show that STAG2 loss cooperates with GATA2 deficiency to drive MDS progression through increased HSC self-renewal and myeloid bias.

Blood Advances · Sep 24, 2026Peer-reviewedCancer Biology

Single-cell mapping of regulatory DNA:Protein interactions

Wei-Yu Chi, Sang-Ho Yoon, Evrim Goksel, Levan Mekerishvili, Joe Pelt, Yiyun Lin, Tamara Prieto, John Zinno, Saravanan Ganesan, Catherine J. Potenski, Franco Izzo, Dan Avi Landau, Ivan Raimondi

This paper introduces D&D-seq, a single-cell method to map DNA:Protein interactions with high specificity and resolution, and applies it to study TF binding in human cells.

Cell · Jun 1, 2026Peer-reviewedGenomics

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

Ke Wang, Shayan Saniei, Nikita Poddar, Isabella G. Martinez, Clifford Chao, Subrina Autar, Persephone Fiore, Saul Carcamo, Meghana Sreenath, Jack H. Peplinski, Rhonda E. Ries, Anna Huo-Chang Mei, Noshin Azra Rahman, Levan Mekerishvili, Miguel Quijada‐Álamo, , Eric Chi Wai So

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

Cancer Discovery · Dec 6, 2025Peer-reviewedCancer Biology

Nanobody-tethered transposition allows for multifactorial chromatin profiling at single-cell resolution

Tim Stuart, Stephanie Hao, Bingjie Zhang, Levan Mekerishvili, Dan Avi Landau, Silas Maniatis, Rahul Satija, Ivan Raimondi

This paper introduces NTT-seq, a method to measure multiple chromatin features at single-cell resolution, and demonstrates its application in immune cells.

bioRxiv · Mar 8, 2022 · PreprintGenomics