Author

Isabella G. Martinez

Columbia UniversityORCID 0000-0002-5372-3873Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Grace S. FreediD· 3 shared Clifford ChaoiD· 2 shared Dan HassoniD· 2 shared Elvin WagenblastiD· 2 shared Ke WangiD· 2 shared Levan MekerishviliiD· 2 shared Miguel Quijada ÁlamoiD· 2 shared Mimi ZhangiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Grace S. FreedORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression

Grace S. Freed, Miguel Quijada Álamo, L Lee, Ke Wang, Nikita Poddar, Subrina Persaud, Saul Carcamo, Persephone Fiore, Emma K Kim, Isabella G. Martinez, Mimi Zhang, Shayan Saniei, Clifford Chao, Levan Mekerishvili, Zayna Diaz, , Elvin Wagenblast

This paper uses a CRISPR-based humanized model to show that STAG2 loss cooperates with GATA2 deficiency to drive MDS progression through increased HSC self-renewal and myeloid bias.

Blood Advances · Sep 24, 2026Peer-reviewedCancer Biology

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

Ke Wang, Shayan Saniei, Nikita Poddar, Isabella G. Martinez, Clifford Chao, Subrina Autar, Persephone Fiore, Saul Carcamo, Meghana Sreenath, Jack H. Peplinski, Rhonda E. Ries, Anna Huo-Chang Mei, Noshin Azra Rahman, Levan Mekerishvili, Miguel Quijada‐Álamo, , Eric Chi Wai So

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

Cancer Discovery · Dec 6, 2025Peer-reviewedCancer Biology

Genetic variation in male mate choice for large females in Drosophila melanogaster

Grace S. Freed, Isabella G. Martinez, Avigayil Lev, Ana‐Maria Anthony Cuadrado, Alison Pischedda

The paper tests for heritable genetic variation in male mate choice for large females in Drosophila melanogaster and finds additive genetic variation in both pre- and post-copulatory components.

Ecology and Evolution · Jan 1, 2025Peer-reviewedEvolutionary Biology