Ryan W. J. Steel

Chemovaccination with a novel antimalarial targeting the late liver stage induces durable immunity against malaria

This paper demonstrates that chemovaccination using antimalarials targeting plasmepsin IX/X induces durable immunity against malaria in mice and shows conservation of the mechanism in P. falciparum.

Temporal expression of liver-stage malaria antigens shapes vaccine efficacy

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling.

The paper shows iron deficiency reduces Plasmodium parasitemia in pregnant women and mice, and iron supplementation does not increase parasitemia when combined with malaria prevention.

The vaccine candidate Liver Stage Antigen 3 is exported during Plasmodium falciparum infection and required for liver-stage development in humanized mice

The paper identifies LSA3 as an exported protein essential for Plasmodium falciparum liver-stage development and presents it as a potential vaccine candidate.