William R. Heath

This paper demonstrates that chemovaccination using antimalarials targeting plasmepsin IX/X induces durable immunity against malaria in mice and shows conservation of the mechanism in P. falciparum.

This study optimizes an mRNA vaccine to enhance liver Trm cell induction by reducing type I interferon responses through improved manufacturing.

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

This study shows that RAS vaccination generates long-lived liver-resident memory T cells specific for abundant sporozoite antigens, which mediate protection but may limit vaccine efficacy against diverse parasite strains.

The paper identifies a neuronal circuit in C. elegans that modulates hydrogen peroxide defenses based on sensory input and bacterial presence.