Daniel Fernandez‐Ruiz

Chemovaccination with a novel antimalarial targeting the late liver stage induces durable immunity against malaria

This paper demonstrates that chemovaccination using antimalarials targeting plasmepsin IX/X induces durable immunity against malaria in mice and shows conservation of the mechanism in P. falciparum.

Temporal expression of liver-stage malaria antigens shapes vaccine efficacy

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

Vγ1+ γδ T cell-derived IL-4 initiates CD8 T cell immunity

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

B cells targeting parasites capture spatially linked antigens to secure T cell help

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination

This study shows that RAS vaccination generates long-lived liver-resident memory T cells specific for abundant sporozoite antigens, which mediate protection but may limit vaccine efficacy against diverse parasite strains.