Sarah Elizabeth Harris

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

The paper shows that imputing DNA methylation loci from epigenome-wide data provides stronger associations with smoking and age than directly measured CpGs.

This study identifies 17 genetic loci associated with sleep duration and lipid levels, offering potential druggable targets for dyslipidemia in individuals with sleep disturbances.

This study compares two glucose receptor systems in yeast, showing they regulate distinct metabolic processes and signaling pathways.

This paper investigates the roles of G protein subunits Gpa2 and Asc1/RACK1 in glucose signaling using transcriptomics and metabolomics in yeast, finding distinct contributions to sugar and amino acid metabolism.

This study expands the genetic landscape of COPD by identifying 82 risk loci, revealing associations with lung function, cell types, and comorbidities.

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.