Ivana Gasic

This study shows that TTC5-dependent tubulin autoregulation maintains microtubule dynamics, cytoskeletal organization, and tissue viability in human 3D models.

The paper shows that γ-tubulin is regulated by the same autoregulatory pathway as α- and β-tubulin, ensuring proper microtubule nucleation and mitotic fidelity.

The paper shows soluble β-tubulins sequester TTC5 to regulate tubulin mRNA decay, with loss of sequestration leading to reduced mRNA levels and chromosome segregation defects.

The paper identifies how TTC5 recruits SCAPER to initiate tubulin mRNA degradation via interaction with the CCR4-NOT complex, linking ribosome-associated mRNA decay to microtubule regulation.