Author

Amal Tiss

Harvard UniversityORCID 0000-0002-4825-5569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 3 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Karla M. Ramos‐TorresiD· 3 shared Pedro BrugarolasiD· 3 shared Lauren L. ZhangiD· 2 shared Yang SuniD· 2 shared Yu‐Peng ZhouiD· 2 shared Alexandra Kapolis· 1 shared Céline CaravagnaiD· 1 shared Clas LinnmaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

Karla M. Ramos‐TorresORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP

Karla M. Ramos‐Torres, Amal Tiss, Kryslaine L. Radomski, Alexandra Kapolis, Kazue Ichino Takahashi, Seresa McDowell, Emiri T. Mandeville, Ji Hyun Park, Lauren L. Zhang, Y. E. Sun, Yu‐Peng Zhou, Eng H. Lo, Regina C. Armstrong, Pedro Brugarolas

This study evaluates [18F]3F4AP PET imaging for detecting demyelination in traumatic brain injury models in mice, showing increased tracer uptake correlating with histological evidence of myelin loss.

Journal of Neurotrauma · Apr 7, 2026Peer-reviewedNeuroscience

Imaging demyelinated axons after spinal cord injuries with PET tracer 3F4AP

Karla M. Ramos‐Torres, Sara Conti, Yu‐Peng Zhou, Amal Tiss, Céline Caravagna, Kazue Takahashi, Miao He, Moses Q. Wilks, Sophie Eckl, Yang Sun, Jason Biundo, Kuang Gong, Zhigang He, Clas Linnman, Pedro Brugarolas

This study introduces a PET tracer, [18F]3F4AP, to image demyelinated axons in spinal cord injuries and shows its ability to detect injury and monitor changes in animal models and humans.

Journal of Nuclear Medicine · Jan 16, 2025Peer-reviewedNeuroscience

Synthesis of K+ channel radioligand 5-methyl-3-fluoro-4-aminopyridine and PET imaging in mice

Yang Sun, Karla M. Ramos‐Torres, Kazue Takahashi, Amal Tiss, Lauren L. Zhang, Pedro Brugarolas

This paper synthesizes [18F]5Me3F4AP, a K+ channel PET radioligand, and demonstrates its brain uptake and kinetics in mice, suggesting it as a potential improved tracer for demyelination imaging.

Bioorganic & Medicinal Chemistry Letters · Jul 19, 2024Peer-reviewedBiochemistry