Author

Kazue Takahashi

Harvard UniversityORCID 0000-0002-9705-0201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:imaging· 3 Organism:rat· 3 Organism:human· 2 Organism:non-human primate· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Pedro BrugarolasiD· 4 shared Yang SuniD· 4 shared Yu‐Peng ZhouiD· 4 shared Karla M. Ramos‐TorresiD· 2 shared Vasily BeloviD· 2 shared Amal TissiD· 1 shared Céline CaravagnaiD· 1 shared Clas LinnmaniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Pedro BrugarolasORCID

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4 papers

Recent·Most cited

Imaging demyelinated axons after spinal cord injuries with PET tracer 3F4AP

Karla M. Ramos‐Torres, Sara Conti, Yu‐Peng Zhou, Amal Tiss, Céline Caravagna, Kazue Takahashi, Miao He, Moses Q. Wilks, Sophie Eckl, Yang Sun, Jason Biundo, Kuang Gong, Zhigang He, Clas Linnman, Pedro Brugarolas

This study introduces a PET tracer, [18F]3F4AP, to image demyelinated axons in spinal cord injuries and shows its ability to detect injury and monitor changes in animal models and humans.

Journal of Nuclear Medicine · Jan 16, 2025Peer-reviewedNeuroscience

Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer 3F4AP

Karla M. Ramos‐Torres, Yang Sun, Kazue Takahashi, Yu‐Peng Zhou, Pedro Brugarolas

This study shows that isoflurane anesthesia inhibits [18F]3F4AP metabolism in mice, leading to higher brain uptake, similar to human studies, and highlights the need to consider anesthesia effects in PET tracer translation.

Journal of Neurochemistry · May 1, 2024Peer-reviewedNeuroscience

Radiochemical Synthesis and Evaluation of 3-methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

Yang Sun, Nicolas J. Guehl, Yu‐Peng Zhou, Kazue Takahashi, Vasily Belov, Maëva Dhaynaut, Sung‐Hyun Moon, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas

The paper describes the synthesis and evaluation of [11C]3Me4AP, a tracer for imaging Kv1 channels in the CNS, showing lower brain uptake and slower kinetics compared to related tracers.

ACS Chemical Neuroscience · Nov 23, 2022Peer-reviewedNeuroscience

Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain

Yu‐Peng Zhou, Yang Sun, Kazue Takahashi, Vasily Belov, Nick Andrews, Clifford J. Woolf, Pedro Brugarolas

This paper develops two 18F-labeled gabapentin derivatives for imaging the α2δ-1 subunit of calcium channels in neuropathic pain, showing increased uptake in injured nerves.

European Journal of Medicinal Chemistry · Aug 17, 2022Peer-reviewedNeuroscience