Author

Laura Bozal‐Basterra

CIC bioGUNEORCID 0000-0002-4858-2199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:biophysical modeling· 2 Assay:scRNA-seq· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Arkaitz CarracedoiD· 4 shared Ianire AstobizaiD· 3 shared Isabel MendizabaliD· 3 shared Natalia Martín-MartíniD· 3 shared Saioa Garcia‐LongarteiD· 3 shared Aida Santos-Martín· 2 shared Aitziber Ugalde‐Olano· 2 shared Amaia Zabala‐LetonaiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Arkaitz CarracedoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer.

Roos Vincken, Samuel Tanner Pasco, Veronica Steri, Laura Bozal‐Basterra, Wilfred F. J. van IJcken, Arkaitz Carracedo, Danny Huylebroeck, Mark M. Moasser, Ana Ruiz-Sáenz

This study identifies PFKFB3 upregulation as a driver of trastuzumab resistance in HER2+ breast cancer through metabolic rewiring and reduced ADCC, with clinical correlations to poor survival.

Biomedicine & Pharmacotherapy · Jan 1, 2026Peer-reviewedCancer Biology

Transcriptional network analysis of PTEN protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Ivana Rondon‐Lorefice, Jose Ignacio Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martín-Martín, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofía Rey, Aida Santos-Martín, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Giovanni Nuciforo, , Isabel Mendizabal

This study analyzes PTEN-deficient prostate tumors to reveal stromal reprogramming and senescent paracrine communication through transcriptional network analysis and single-cell RNA-Seq.

Molecular Oncology · Nov 17, 2025Peer-reviewedCancer Biology

The transcriptional landscape of metastatic hormone-naive prostate cancer

Natalia Martín-Martín, Saioa Garcia‐Longarte, Jon Corres-Mendizabal, Uxue Lazcano, Ianire Astobiza, Laura Bozal‐Basterra, Nicolás Herranz, Hielke van Splunder, Onintza Carlevaris, Mikel Pujana-Vaquerizo, María Teresa Blasco, Ana María Aransay, Antonio Rosino, Julián Tudela, Daniel Jimenez, , Arkaitz Carracedo

This study characterizes the transcriptome of metastatic hormone-naive prostate cancer, identifying stroma remodelling and SOX11's role in metastasis.

Genome biology · Jun 3, 2025Peer-reviewedCancer Biology

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

Laura Bozal‐Basterra, María-Camila Salazar, Ana Margarida Ferreira Campos, Margherita Demicco, Daniel R. Schmidt, Klaudia Sobczak, June Ereño‐Orbea, Patricia Altea‐Manzano, Ainara Miranda Villanueva, Belen Martinez-Laosa, Saioa Garcia‐Longarte, María Ponce-Rodriguez, Isabel Mendizabal, Onintza Carlevaris, Ianire Astobiza, , Arkaitz Carracedo

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

bioRxiv · Jun 2, 2025 · PreprintCancer Biology