Anna Szlachcic

This study designs high-affinity ligands for the E3 ligase GID4 to enable targeted protein degradation, identifying conformational changes and potential degrader structures, though degradation efficacy remains to be optimized.

The paper identifies ABS-752, a molecular glue prodrug that degrades GSPT1 and NEK7 in HCC cells, showing potent in vitro and in vivo activity.

The paper optimizes expression and characterizes the stability of TNFR1 R347A, MyD88, and IRAK4 death domains in E. coli.

This study compares the expression of three HECT E3 ligases in E. coli, finding that lower temperatures improve solubility and yield, while full-length proteins are less successfully expressed than isolated domains.