Author

Han J. M. P. Verhagen

Amsterdam UMC Location University of AmsterdamORCID 0000-0002-4866-5840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Emile van den AkkeriD· 2 shared Anna-Karina FelderiD· 1 shared Anne M. Kokke· 1 shared Carlijn Kuijk· 1 shared Carlijn VoermansiD· 1 shared Gerard J. van Mierlo· 1 shared Laurens Rutgers· 1 shared Marjon J.A.M. Verstegen· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Emile van den AkkerORCID

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2 papers

Recent·Most cited

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters

Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen, Rezin Majied, Marjon J.A.M. Verstegen, Thijs C. J. Verheul, Rebecca Mohnani, Richard Gremmen, Peter H.L. Krijger, Sjaak Philipsen, Emile van den Akker, Wouter L. de Laat

The paper shows that deleting intervening DNA can bring enhancers closer to silenced genes, reactivating their expression in adult cells.

bioRxiv · Jan 13, 2025 · PreprintMolecular Biology

Optimized guide RNA selection recommendations for using spCas9 gene editing in human hematopoietic stem and progenitor cells

Han J. M. P. Verhagen, Carlijn Kuijk, Anne M. Kokke, Laurens Rutgers, Santhe A. van der Meulen, Gerard J. van Mierlo, Carlijn Voermans, Emile van den Akker

The paper evaluates sgRNA design for spCas9-RNP gene editing in HSPCs, showing in vitro screening outperforms in silico models and no adverse effects on cell function.

bioRxiv · Dec 18, 2020 · PreprintMolecular Biology