BiochemistryNature CommunicationsPeer-reviewed
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
Piotr Drączkowski, Szu-Ni Chen, Ting Chen…·Shang‐Te Danny Hsu
The paper reports cryo-EM structures of the human 26S proteasome bound to K11/K48-branched ubiquitin chains, revealing a multivalent recognition mechanism involving new binding sites for K11 and alternating K11-K48 linkages.