Author

Isabel Sierra

University of PennsylvaniaORCID 0000-0002-4875-2741Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:Hi-C· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Montserrat C. AngueraiD· 3 shared Ashley L. CookiD· 2 shared Claudia D. LovelliD· 2 shared Eric F. JoyceiD· 2 shared Han-Seul RyuiD· 2 shared Jennifer E. Phillips‐CreminsiD· 2 shared R. Jordan BarnettiD· 2 shared Son C. NguyeniD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Montserrat C. AngueraORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tissue-Specific and NF-kappaB-Independent Xist RNA Localization Patterns in Female Intestinal, Blood, and Muscle Progenitors

Claudia D. Lovell, Isabel Sierra, Emma M. Welter, Donavon Sandoval-Heglund, Ning Li, Ashley Vanderbeck, Christopher J. Lengner, Christoph Lepper, Montserrat C. Anguera

The paper investigates Xist RNA localization patterns in female progenitor cells from different tissues, showing tissue-specific and NF-kappaB-independent mechanisms of X chromosome inactivation.

bioRxiv · Aug 30, 2025 · PreprintGenetics

B cell stimulation changes the structure and higher-order organization of the inactive X chromosome

Isabel Sierra, Natalie E. Toothacre, Robin H. van der Weide, Claudia D. Lovell, Son C. Nguyen, R. Jordan Barnett, Ashley L. Cook, Han-Seul Ryu, Sarah Pyfrom, Harrison Wang, Daniel P. Beiting, Jennifer E. Phillips‐Cremins, Eric F. Joyce, Montserrat C. Anguera

This study investigates how B cell stimulation affects the structure and organization of the inactive X chromosome, revealing dynamic changes in TAD boundaries and Xi compaction.

Cell Reports · Feb 26, 2025Peer-reviewedGenetics

Remodeling and compaction of the inactive X is regulated by Xist during female B cell activation

Isabel Sierra, Son C. Nguyen, R. Jordan Barnett, Ashley L. Cook, Han-Seul Ryu, Zachary T. Beethem, Jennifer E. Phillips‐Cremins, Eric F. Joyce, Montserrat C. Anguera

This study shows that Xist regulates Xi compaction and TAD boundaries in B cells, impacting XCI maintenance and X-linked gene expression.

bioRxiv · Oct 19, 2022 · PreprintGenetics