Daniel P. Beiting

Ablation of a maternal Cryptosporidium mRNA-binding protein results in sterile sporozoites

The paper identifies an RNA-binding protein essential for female gamete development and sporozoite infectivity in Cryptosporidium by analyzing single-cell data and conducting conditional ablation experiments.

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

Human wastewater contamination drives the emergence of novel multidrug resistant bacteria in the Galapagos marine ecosystem.

This study maps wastewater contamination in the Galapagos and finds increased antimicrobial resistance genes and multidrug-resistant bacteria linked to human activity.

Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance

The paper identifies genomic heterogeneity at the NDH2 locus in Cryptosporidium species that contributes to clofazimine resistance through adaptive recombination.

SPTBN2 promotes an immunosuppressive tumor microenvironment and cross-resistance to anti-cancer therapies

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection

The paper identifies genomic loci associated with virulence in Cryptosporidium parvum by analyzing genetic crosses and whole-genome sequencing in mice.

Defining neuronal responses to the neurotropic parasite Toxoplasma gondii

The paper compares neuronal transcriptional responses to Toxoplasma gondii and RNA viruses, identifying conserved and pathogen-specific immune responses in neurons.

A Wildlife Health Outbreak Response Table-top Exercise for Pandemic Preparedness Planning

This paper describes a table-top exercise to evaluate multi-agency response to a hypothetical zoonotic disease outbreak and identifies challenges and recommendations for improving cross-agency coordination.

Short-term alterations in dietary amino acids override host genetic susceptibility and reveal mechanisms of Salmonella Typhimurium small intestine colonization

The paper shows that a diet rich in L-amino acids overrides genetic resistance in mice, promoting Salmonella Typhimurium ileal colonization through microbiota-dependent mechanisms.

B cell stimulation changes the structure and higher-order organization of the inactive X chromosome

This study investigates how B cell stimulation affects the structure and organization of the inactive X chromosome, revealing dynamic changes in TAD boundaries and Xi compaction.

Improved eukaryotic detection compatible with large-scale automated analysis of metagenomes

This paper introduces CORRAL, a tool for detecting eukaryotes in metagenomic data, showing it can identify novel strains and integrate with web-based analysis tools.