Author

Natalie E. Toothacre

University of PennsylvaniaORCID 0000-0002-4500-7965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Montserrat C. AngueraiD· 3 shared Claudia D. LovelliD· 2 shared Ashley L. CookiD· 1 shared Christopher D. SchareriD· 1 shared Daniel P. BeitingiD· 1 shared Eric F. JoyceiD· 1 shared Han-Seul RyuiD· 1 shared Harrison WangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersGenetics

Montserrat C. AngueraORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Xist Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes

Claudia D. Lovell, Nikhil Jiwrajka, Natalie E. Toothacre, Hayley K. Amerman, Michael P. Cancro, Montserrat C. Anguera

This study shows that deleting Xist in B cells of female mice leads to SLE-like symptoms, suggesting XCI impairment contributes to the female bias in SLE.

Cell Reports · Jun 1, 2026Peer-reviewedImmunology

Xist RNA Dependent and Independent Mechanisms Regulate Dynamic X Chromosome Inactivation in B Lymphocytes

Natalie E. Toothacre, Kiara L. Rodríguez-Acevedo, Keenan J Wiggins, Christopher D. Scharer, Montserrat C. Anguera

The paper investigates Xist RNA's role in X chromosome inactivation dynamics in B cells, finding Xist-dependent and independent epigenetic mechanisms that maintain XCI memory.

Cell Reports · Apr 1, 2026Peer-reviewedGenetics

B cell stimulation changes the structure and higher-order organization of the inactive X chromosome

Isabel Sierra, Natalie E. Toothacre, Robin H. van der Weide, Claudia D. Lovell, Son C. Nguyen, R. Jordan Barnett, Ashley L. Cook, Han-Seul Ryu, Sarah Pyfrom, Harrison Wang, Daniel P. Beiting, Jennifer E. Phillips‐Cremins, Eric F. Joyce, Montserrat C. Anguera

This study investigates how B cell stimulation affects the structure and organization of the inactive X chromosome, revealing dynamic changes in TAD boundaries and Xi compaction.

Cell Reports · Feb 26, 2025Peer-reviewedGenetics