Miao Zhao

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

This paper introduces FFPE-ATAC, a method for profiling chromatin accessibility in formalin-fixed paraffin-embedded tissues, demonstrating its effectiveness with colorectal cancer samples.

Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

The paper investigates extrachromosomal DNA (ecDNA) in gastric cardia adenocarcinoma, finding associations with chromothripsis, DNA damage, and prognosis based on oncogene amplicons.

Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion

This study shows that conditional PAK4 gene depletion in mice does not impair mammary gland development, suggesting PAK4 may not be essential for normal development but could be relevant in breast cancer.