Michael G. Rosenfeld

The paper identifies PTBP1 as a stress-inducible factor that reprograms neuronal function and activates cellular senescence through transcriptional changes.

This paper identifies CDC14A and KMT5A as regulators of concentric vs. eccentric cardiac remodeling through epigenomic control of gene transcription, with CDC14A as a potential therapeutic target for heart failure.

This study identifies that rAAV toxicity in dividing cells results from depletion of PARP1 and other DNA damage response proteins, leading to replication stress and cell death.

The paper uses live cell imaging to study chromosomal dynamics during estrogen receptor-mediated transcriptional bursts and non-burst phases, revealing changes in locus mobility and condensate formation.

This study shows RSV uses liquid-liquid phase separation to shield viral RNA from the OAS-RNase L antiviral pathway, enabling immune evasion.

Autism-like MEF2C+/- patient hiPSC models show miRNA-mediated overproduction of astrocytes and hyperactivity of neurons.

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

The paper identifies LOAD risk genes through systems biology and shows their impact on memory function via neuronal endosomal dysfunction in C. elegans.

This paper introduces two 3C-derived methods, Tri-4C and Tri-HiC, for ultrafine mapping of chromatin interactions at 100 basepair resolution, revealing regulatory genome architecture and enhancer-promoter loops.

The paper identifies a functional variant in the 9p21.3 locus associated with glaucoma risk and shows it increases p16INK4a expression by disrupting YY1 binding.

This study uses single-nuclei multi-omics analysis to identify molecular and cellular changes in human ovarian ageing and links genetic variants to age at natural menopause.

The paper identifies a reversible transcriptional switch in cardiac fibroblasts that governs fibroblast plasticity and contributes to chronic heart disease, with MEOX1 as a key regulator.

The paper identifies allele-specific NKX2-5 binding variants associated with EKG traits by integrating iPSC-CM data and GWAS, showing their role in heart rate loci and cardiac enhancer activity.

The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.

The paper shows LSD1-mediated enhancer silencing limits RA signaling duration during endocrine cell development by suppressing persistent enhancer activity.

This study identifies GPS2 as a mediator of mitochondrial retrograde signaling and a key activator of nuclear-encoded mitochondrial genes, revealing a novel mitochondria-nuclear communication pathway.