Susan E. Tsutakawa

Experimental Data Driven AI Framework for Flexible Protein Conformational Reconstruction

AlphaSAXS uses SAXS data to guide AI in reconstructing accurate protein conformations, improving upon sequence-only models by incorporating experimental constraints.

Predicting pose distribution of protein domains connected by flexible linkers is an unsolved problem

The paper evaluates computational methods for predicting interdomain pose distributions in D-L-D proteins using NMR and SAXS data, finding none accurately match experimental results.

Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish

The paper identifies structural differences in zebrafish α4 chain of type IV collagen and shows its conserved anti-angiogenic activity compared to humans.