Karsten Bach

This study examines the molecular and functional effects of TDP-43 loss in human induced neurons, revealing cell-type-specific gene expression and splicing changes, and a hyperexcitable phenotype in both glutamatergic and cholinergic motor neurons.

ISCHIA identifies spatial co-occurrence patterns in healthy and inflamed human tissues using spatial transcriptomics data.

Sphere-sequencing identifies zonated genes and ligand-receptor interactions in mouse metastatic liver microenvironments at single cell resolution.

This paper introduces NPARC, a non-parametric method for analyzing thermal proteome profiles to identify drug-binding proteins with improved specificity and sensitivity.

The paper quantifies barcode swapping in single-cell RNA-seq data and develops an algorithm to remove swapped reads, reducing artifacts in droplet-based experiments.