Claire Koenig

KRysin, a bispecific protease, improves plasma and phosphoproteomics by enhancing digestion completeness and PTM coverage compared to trypsin.

Orbitrap Astral Zoom upgrades enable 270 Hz DIA scanning, identifying 7184 protein groups at 500 samples/day and >12,000 proteins from fractionated HEK293 in 2.7 h.

The paper presents a comprehensive human phosphoproteome atlas with over 200,000 phosphosites, improving phosphoproteomics speed and accuracy, and identifies kinase activity patterns linked to drug sensitivity.

This paper introduces a high-throughput proteomics method for biological sex identification from archaeological human dental enamel, achieving high accuracy and scalability.

The paper optimizes automated phosphopeptide enrichment to improve phosphoproteome coverage and sensitivity in low-input samples using LC-MS/MS.

The paper introduces hybrid-DIA, a method combining targeted and discovery phosphoproteomics for single spheroids, showing comparable accuracy to existing methods while profiling the global phosphoproteome.

The paper develops a high-throughput workflow for subcellular proteome and phospho-proteome profiling and applies it to study EGFR signaling and stress responses in cells.