ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant calling
Zhi-Can Fu, Chuanxin Zhang, Yelian Yan, Yuxin Xu, Xiaoyu Yin, Tietuo Tao, Peng Lu, Yalin Liang, Haiyang Wu, Wentao Cui, Runtong Hou, Xuepeng Chen, Yuwen Ke, Yanqiang Li, Z Chen, , Shenli Yuan
ANCHOR improves variant calling and allele-specific expression analysis in single-cell long-read RNA-seq by integrating haplotype-aware methods and beta-binomial modeling.
bioRxiv · Jun 11, 2026 · PreprintBioinformatics