Yuwen Ke

ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant calling

ANCHOR improves variant calling and allele-specific expression analysis in single-cell long-read RNA-seq by integrating haplotype-aware methods and beta-binomial modeling.

Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development

This study creates a spatial transcriptomic atlas of mouse lung development, revealing gene expression patterns, regulatory mechanisms, and cell-cell communication networks.

Intense oocyte competition builds the female reproductive reserve in mice

The paper uses live imaging and single-cell sequencing to show that oocyte competition in mice enhances quality through autophagy-driven debris absorption, essential for fertility.

Comprehensive identification of fetal cis-regulatory elements in the human genome by single-cell multi-omics analysis

The paper identifies fetal cis-regulatory elements in the human genome using single-cell multi-omics analysis, revealing thousands of organ- and cell-type-specific regulatory elements.