Jérémy Dufloo

Anticipatory discovery of entry inhibitors against emerging viruses guided by viral phylogeny

The paper identifies entry inhibitors against emerging viruses using a phylogenetic framework, finding drugs with broad antiviral activity across related viral RBPs.

Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses

This study shows that sialic acids restrict entry of non-influenza orthomyxoviruses, unlike influenza viruses, and identifies mutations that can overcome this restriction.

Dipeptidase 1 is a functional receptor for coronavirus PHEV

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

Identification and characterization of novel bat coronaviruses in Spain

This study identifies six novel bat coronaviruses in Spain, three of which are potentially new species, and finds one can use human ACE2 receptor, indicating zoonotic potential.

Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein

This study uses experimental evolution to identify mutations in the SADS-CoV spike protein that enhance its ability to infect human cells, potentially increasing its zoonotic potential.