Rafael Sanjuán

Anticipatory discovery of entry inhibitors against emerging viruses guided by viral phylogeny

The paper identifies entry inhibitors against emerging viruses using a phylogenetic framework, finding drugs with broad antiviral activity across related viral RBPs.

Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses

This study shows that sialic acids restrict entry of non-influenza orthomyxoviruses, unlike influenza viruses, and identifies mutations that can overcome this restriction.

Phenotypic Heterogeneity Shapes Phage Resistance and Cocktail Efficacy in Klebsiella pneumoniae

This study shows that phenotypic heterogeneity in Klebsiella pneumoniae affects phage resistance and cocktail efficacy, with acapsular variants being more susceptible to phages and sustaining cocktail effectiveness under selective pressure.

Dipeptidase 1 is a functional receptor for coronavirus PHEV

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases

This paper models phage depolymerase capsular tropism using graph neural networks and sequence clustering, showing predictive ability and transferability to lytic phages.

Rodents as Potential Reservoirs for Toroviruses

The paper identifies a novel torovirus in a dormouse, suggesting rodents may be a reservoir for toroviruses and highlighting their potential for cross-species transmission.

Atypical Replication Error Pattern and Limited Repair Efficiency Contribute to Elevated Mutation Rate in Phage lambda

This study measures the mutation rate of phage lambda and finds it is higher than its host E. coli but not significantly increased by MMR inactivation.

Identification and characterization of novel bat coronaviruses in Spain

This study identifies six novel bat coronaviruses in Spain, three of which are potentially new species, and finds one can use human ACE2 receptor, indicating zoonotic potential.

Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein

This study uses experimental evolution to identify mutations in the SADS-CoV spike protein that enhance its ability to infect human cells, potentially increasing its zoonotic potential.

Phenotypic resistance to phage infection through capsule expression shutdown in Klebsiella pneumoniae

The paper shows that Klebsiella pneumoniae can resist phage infection through reversible downregulation of capsule biosynthesis without genetic mutations.

Complete genomes of DNA viruses in faecal samples from small terrestrial mammals in Spain

The paper identifies 25 complete or near-complete DNA virus genomes from small terrestrial mammals in Spain, including 18 potential new species or types.

Genetic diversity and cross-species transmissibility of bat-associated picornaviruses from Spain

The paper identifies new picornaviruses from Spanish bats, including a potential plant host calhevirus, highlighting their geographic distribution and interspecies transmissibility.

DepoScope: accurate phage depolymerase annotation and domain delineation using large language models

DepoScope uses large language models to accurately annotate phage depolymerases and their domains, improving detection through sequence and amino-acid level predictions.

A new clade of pararetroviruses distantly related to hepadnaviruses and nackednaviruses

The paper describes a new pararetrovirus found in an insectivorous bat, which forms a basal clade distinct from hepadnaviruses and nackednaviruses, suggesting ancestral non-enveloped pararetroviruses.

Full genome sequencing of dozens of new DNA viruses found in Spanish bat faeces

The paper uses viral metagenomics to analyze bat fecal samples, identifying 50 complete or near-complete DNA virus genomes, including 28 potential new species, expanding the known European DNA virus diversity.