Johann Brenner

Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

Exploring shaped focused ion beams for lamella preparation

This paper explores the use of shaped focused ion beams for preparing TEM lamellae, demonstrating the feasibility of cellular lamella milling with an ion knife.

Making plant tissue accessible for cryo-electron tomography

This paper describes optimized cryo-ET sample preparation workflows for plant tissues, achieving subnanometer resolution through targeted FIB milling and lamella trimming.

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

Period Doubling Bifurcations in a Forced Cell-Free Genetic Oscillator

The paper experimentally demonstrates period doubling and quadrupling in a synthetic genetic oscillator under external perturbations.