C.H. Arrowsmith

The paper shows that (R,R)-59, a SETDB1 ligand, enhances SETDB1-mediated methylation of Akt1 and promotes cell proliferation.

The paper designs over ten thousand {square}{beta}{beta}{square} proteins, identifies stability determinants, and demonstrates how high-throughput methods can improve protein design success rates.

This study identifies LSD1 as a repressor of a neonatal/reparative gene program in adult intestinal epithelium, showing its role in Paneth cell differentiation and regenerative capacity.

The paper investigates the dynamic structure of the MLL1 catalytic complex and shows it can be disrupted by pharmacological agents targeting specific interaction sites.

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.

The paper presents a chemical probe collection for studying protein methyltransferases, showing their utility in modulating epigenetic marks and affecting T cell differentiation.