Proximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a putative role for spinophilin in protein homeostasis.
Emily T. Claeboe, Keyana L. Blake, Nikhil R. Shah, Cameron W. Morris, Basant Hens, Brady K. Atwood, Sabrina Absalon, Amber L. Mosley, Emma H. Doud, Anthony J. Baucum
The paper uses ID-oPD to map spinophilin's interactome, identifying proteins involved in mRNA processing and translation, and suggests a role in synaptic protein expression.
bioRxiv · Jan 23, 2025 · PreprintNeuroscience