Brady K. Atwood

Proximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a putative role for spinophilin in protein homeostasis.

The paper uses ID-oPD to map spinophilin's interactome, identifying proteins involved in mRNA processing and translation, and suggests a role in synaptic protein expression.

Deletion of endocannabinoid synthesizing enzyme DAGLα from cerebellar Purkinje cells decreases social preference and elevates anxiety

This study shows that deleting DAGLα in cerebellar Purkinje cells in mice leads to reduced social preference and increased anxiety.

Sex-dependent, lateralized engagement of anterior insular cortex inputs to the dorsolateral striatum in binge alcohol drinking

The paper investigates sex-dependent and lateralized changes in anterior insular cortex inputs to the dorsolateral striatum during binge alcohol consumption in mice.

Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: a multi-modal magnetic resonance study

This study investigates the effects of prenatal methadone exposure on cerebral biochemistry and microstructure in mice using MRS and dMRI, finding reduced metabolites and altered microstructural metrics.

Prenatal methadone exposure selectively alters protein expression in primary motor cortex: implications for synaptic function

This study investigates how prenatal methadone exposure affects protein and phosphoprotein levels in specific brain regions of mice, showing unique changes in the primary motor cortex linked to synaptic function.

Spinophilin limits metabotropic glutamate receptor 5 scaffolding to the postsynaptic density and cell type-specifically mediates excessive grooming

The paper investigates the role of spinophilin in mediating mGluR5-dependent repetitive motor dysfunction in striatal neurons, showing subtype-specific effects on grooming behavior and synaptic plasticity.

HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum

This study identifies HCN1 channels as essential for MOR-LTD at AIC inputs to DLS, revealing distinct molecular mechanisms for MOR and cannabinoid LTD.

Anterior insular cortex inputs to the dorsolateral striatum govern the maintenance of binge alcohol drinking

The paper shows that binge drinking alters glutamatergic synapses from the anterior insular cortex to the dorsolateral striatum, which maintains binge drinking behavior in mice.

Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

This study examines the effects of prenatal methadone exposure on mouse offspring, finding impairments in physical growth, sensorimotor behavior, and motor neuron function.

Basal Ganglia role in learning rewarded actions and executing previously learned choices: healthy and diseased states

This paper models the basal ganglia's role in learning and executing rewarded actions, showing it is critical for learning but not for expressing previously learned choices, and identifies how disease states impair these processes.