This study shows that spinophilin enhances D2R interaction with cytosolic proteins, contributing to D2R agonist-induced locomotor suppression in Parkinson's disease.

Journal of Pharmacology and Experimental Therapeutics · Dec 4, 2025Peer-reviewedNeuroscience

Proximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a putative role for spinophilin in protein homeostasis.

Emily T. Claeboe, Keyana L. Blake, Nikhil R. Shah, Cameron W. Morris, Basant Hens, Brady K. Atwood, Sabrina Absalon, Amber L. Mosley, Emma H. Doud, Anthony J. Baucum

The paper uses ID-oPD to map spinophilin's interactome, identifying proteins involved in mRNA processing and translation, and suggests a role in synaptic protein expression.

bioRxiv · Jan 23, 2025 · PreprintNeuroscience

Spinophilin limits metabotropic glutamate receptor 5 scaffolding to the postsynaptic density and cell type-specifically mediates excessive grooming

Cameron W. Morris, Darryl S. Watkins, Nikhil R. Shah, Taylor Pennington, Basant Hens, Guihong D. Qi, Emma H. Doud, Amber L. Mosley, Brady K. Atwood, Anthony J. Baucum

The paper investigates the role of spinophilin in mediating mGluR5-dependent repetitive motor dysfunction in striatal neurons, showing subtype-specific effects on grooming behavior and synaptic plasticity.

Biological Psychiatry · Dec 13, 2022Peer-reviewedNeuroscience

Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

Gregory G. Grecco, Briana E. Mork, Jui-Yen Huang, Corinne E. Metzger, David L. Haggerty, Kaitlin C. Reeves, Yong Gao, Hunter Hoffman, Simon N. Katner, Andi R. Masters, Cameron W. Morris, Erin A Newell, Eric A. Engleman, Anthony J. Baucum, Jiuen Kim, , Brady K. Atwood

This study examines the effects of prenatal methadone exposure on mouse offspring, finding impairments in physical growth, sensorimotor behavior, and motor neuron function.

eLife · Mar 15, 2021Peer-reviewedNeuroscience

Spinophilin limits GluN2B-containing NMDAR activity and sequelae associated with excessive hippocampal NMDAR function.

Asma B. Salek, Ruchi Bansal, Nicolas F. Berbari, Anthony J. Baucum

This study shows that spinophilin modulates GluN2B-containing NMDAR activity by affecting phosphorylation, surface expression, and calcium influx, leading to changes in apoptosis and cognitive flexibility.

bioRxiv · Dec 30, 2020 · PreprintNeuroscience

Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells

Kirstin B. VanderWall, Ridhima Vij, Sarah K. Ohlemacher, Akshayalakshmi Sridhar, Clarisse M. Fligor, Elyse M. Feder, Michael Edler, Anthony J. Baucum, Theodore Cummins, Jason S. Meyer

This study shows that astrocytes accelerate the functional maturation of retinal ganglion cells derived from human pluripotent stem cells in vitro.

Stem Cell Reports · Jan 10, 2019Peer-reviewedNeuroscience