Author

Shinya Sakaguchi

Medical University of ViennaORCID 0000-0002-0591-2469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Wilfried EllmeieriD· 4 shared Lisa SandneriD· 3 shared Nicole BoucheroniD· 3 shared Alexander LercheriD· 2 shared Andreas BergthaleriD· 2 shared Anna Ohradanova‐RepiciD· 2 shared Ci ZhuiD· 2 shared Claudia Daniela FuchsiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Wilfried EllmeierORCID

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4 papers

Recent·Most cited

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

Ramona Rîca, Monika Waldherr, Emi Miyakoda, Ana P. Kutschat, Marlene Schülein, Jing Zhang, Ricardo Alfredo Orbegozo-Medina, Lisa Sandner, Valentina Stolz, Darina Waltenberger, Thomas Krausgruber, Christoph Bock, Nicole Boucheron, Davide Seruggia, Wilfried Ellmeier, Shinya Sakaguchi

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

The Journal of Experimental Medicine · May 21, 2025Peer-reviewedImmunology

Transcriptional control of adipogenesis by PATZ1

Sanil Patel, Njeri Z. R. Sparman, Shani Sadeh, Jeixin Wang, Julian P. Whitelegge, Susan K. Fried, Hironori Waki, Claudio J. Villanueva, Marcus Michael Seldin, Shinya Sakaguchi, Wilfried Ellmeier, Peter Tontonoz, Prashant Rajbhandari

This study identifies PATZ1 as an adipogenic transcription factor that promotes adipogenesis through DNA binding and protein interactions, and its loss protects against diet-induced obesity.

bioRxiv · May 24, 2022 · PreprintMolecular Biology

24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells

Ci Zhu, Nicole Boucheron, Ramona Rîca, Valentina Stolz, Emina Halilbasic, Thierry Claudel, Osamah Al-Rubaye, Alexander Lercher, Maximilian Baumgartner, Lisa Sandner, Teresa Preglej, Marlis Alteneder, Veronika Mlitz, Claudia Daniela Fuchs, Daniela Hainberger, , Michael A Trauner

This paper shows that NorUDCA reduces TH17/Treg imbalance and intestinal inflammation by inhibiting glutaminolysis and mTORC1 signaling in TH17 cells.

bioRxiv · Feb 10, 2022 · PreprintMolecular Biology

24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

Ci Zhu, Nicole Boucheron, André C. Müller, Peter Májek, Thierry Claudel, Emina Halilbasic, Hatoon Baazim, Alexander Lercher, Csilla Viczenczová, Daniela Hainberger, Teresa Preglej, Lisa Sandner, Marlis Alteneder, Alexandra Franziska Gülich, Matarr Khan, , Michael A Trauner

This study shows that NorUDCA modulates CD8+ T cell metabolism and function, reducing hepatic inflammation in a mouse model of immune-mediated liver disease.

Journal of Hepatology · Jul 7, 2021Peer-reviewedMolecular Biology