Mikkel Heide Schierup

This paper introduces BBQ, a tool that improves rare somatic variant calling by modeling sample-specific error rates using overlapping reads, reducing false positives compared to existing tools.

The paper curates a genome-scale nucleotide diversity panel of non-human primates using ploidy-aware variant calling and multiple-genome alignment.

The paper analyzes X-linked and Y-linked ampliconic gene families in primates, finding pervasive positive selection on X-linked genes and purifying selection on Y-linked genes.

The paper tests the drift-barrier hypothesis by analyzing mutation rates in nine-spined stickleback populations, finding a negative correlation between mutation rates and effective population size.

The paper investigates mutation rates in 43 dog breeds, finding stable rates influenced by parental age and breed-specific differences in mutation accumulation.

This study shows that sociality in spiders is linked to lower germline mutation rates, despite small population sizes and reduced selection pressure.

The paper estimates de novo mutation rates in three-spined sticklebacks using family trios and finds a mutation rate of 5.05 x 10^-9/bp/gen with a positive correlation between mutation rate and recombination rate.

The paper introduces a method to estimate gene conversion tract length and rate from PacBio HiFi data, showing low visibility of NCO events in human sperm due to low SNV density.

This study uses phylogenetic path analysis to examine how life history traits affect population dynamics metrics like effective population size and density across mammalian species.

This study uses long-read sequencing to analyze gene conversion and crossover events in human, chimpanzee, and gorilla testes and sperm, revealing species-specific patterns and GC bias in gene conversion.

This study investigates the genomic consequences of sociality in spiders, finding that transitions to sociality lead to reduced effective population size and genomic diversity, potentially causing extinction.

The paper estimates de novo mutation rates in two marine populations of nine-spined sticklebacks using family pedigrees and whole genome sequencing, finding rates lower than commonly used substitution rates.

The paper uses primate genetic data to predict human variant pathogenicity with a deep learning classifier trained on 4.3 million common missense variants.

This study presents whole-genome data from 233 primate species, revealing patterns of genetic diversity, mutation rates, and recurrent missense mutations across primate clades.

The paper analyzes introgression and selection patterns in symbiosis genes within Rhizobium leguminosarum isolates, finding limited introgression confined to plasmids and chromosomal islands.

The paper develops a method to sequence and assemble a human Y chromosome of African origin using native DNA and nanopore sequencing, achieving high continuity and enabling epigenetic modification detection.

The paper identifies extreme selective sweeps on the human X chromosome that displaced Neanderthal admixture around 50,000 years ago, suggesting a population without Neanderthal admixture contributed these haplotypes.

The paper introduces a method to detect archaic introgression in genomes without archaic reference genomes, finding more Denisovan admixture and differences in admixture timing in Papuans.

The paper estimates mutation rates in great apes and finds a recent slowdown in the human mutation rate per year compared to other species.