Author

Christopher Gager

University of Notre DameORCID 0009-0002-3141-4890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:C. elegans· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alyssa Ann La BellaiD· 2 shared Ana Lidia Flores‐MirelesiD· 2 shared Armando M. MarrufoiD· 2 shared Felipe Hiram Santiago-TiradoiD· 2 shared Kurt N. Kohler· 2 shared Catherine May May HubbardiD· 1 shared Chloe L. P. Obernuefemann· 1 shared Deborah L. DonahueiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMicrobiology

Alyssa Ann La BellaORCID

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2 papers

Recent·Most cited

The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment

Alyssa Ann La Bella, Nicholas C Gervais, Kurt N. Kohler, Hope Akegbe, Chloe L. P. Obernuefemann, Christopher Gager, Catherine May May Hubbard, Armando M. Marrufo, Ilse Denise Jacobsen, Rebecca S. Shapiro, Michael G. Caparon, Scott J. Hultgren, Ana Lidia Flores‐Mireles, Felipe Hiram Santiago-Tirado

This study identifies the Efg1 regulon active in C. albicans during growth in human urine, validates its clinical relevance in catheter samples, and characterizes key downstream factors involved in fungal CAUTI.

Proceedings of the National Academy of Sciences · Jul 20, 2026Peer-reviewedMicrobiology

The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI

Armando M. Marrufo, Jonathan J. Molina, Christopher Gager, Marissa Jeme Andersen, Alyssa Ann La Bella, Elizabeth R. Lucas, Ellsa Wongso, Tamanna Urmi, Kassandra Arias-Parbul, Railyn Webster, Peter V. Stuckey, Kurt N. Kohler, Deborah L. Donahue, Victoria A. Ploplis, Matthew J. Flick, , Ana Lidia Flores‐Mireles

This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.

bioRxiv · Jul 16, 2024 · PreprintImmunology