This study shows that Candida-Klebsiella interactions enhance fungal virulence and tissue pathology by rewiring fungal morphogenesis and host immune responses.

bioRxiv · May 7, 2026 · PreprintMicrobiology

Thyroid Hormone Receptor Beta Signaling is a Targetable Driver of Prostate Cancer Growth

Aleksandra Fesiuk, Daniel Pölöske, Elvin D. de Araujo, Geordon A. Frere, Timothy B. Wright, Gary Tin, Yasir S. Raouf, Olasunkanmi O. Olaoye, Ji Sung Park, Nicolas Blavet, Boris Tichý, Michaela Schlederer, Sandra Högler, Michael Wolf, Cécile Philippe, , Lukas Kenner

This study identifies TRβ as a driver of prostate cancer growth and shows that NH-3 inhibits PCa cell proliferation and tumor growth, particularly in castration-resistant models.

Molecular Cancer · Oct 14, 2025Peer-reviewedCancer Biology

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

Christina Sternberg, Martin Raigel, Tanja Limberger, Karolína Trachtová, Michaela Schlederer, Desiree Lindner, Petra Kodajova, Jiaye Yang, Roman Ziegler, Jessica Kalla, Stefan Stoiber, Saptaswa Dey, Daniela Zwolanek, Heidi Anne Neubauer, Monika Oberhuber, , Lukas Kenner

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

Molecular Cancer · Oct 31, 2024Peer-reviewedCancer Biology