Lorenzo Gallicchio

Nuclear stress bodies enable a germline-specific transcriptional stress response in Drosophila

This study identifies nuclear stress bodies in Drosophila germline that mediate a stress response by delaying Hsf-dependent transcription and enabling selective expression of molecular chaperones over transposable elements.

The CFII components PCF11 and Cbc change subnuclear localization as cells differentiate in the male germ line adult stem cell lineage

The paper shows that PCF11 and Cbc change their subnuclear localization during male germ cell differentiation in Drosophila.

An RNA binding regulatory cascade controls the switch from proliferation to differentiation in the Drosophila male germ line stem cell lineage

The paper shows that Bam represses how RNA to control the switch from proliferation to differentiation in Drosophila male germ line stem cells.

A cell-type specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage

The paper identifies a cell-type specific surveillance complex that represses cryptic promoters during differentiation in Drosophila male germ line stem cells.

Differentiating spermatogonia trigger somatic support cells to form septate junctions required for germ cell survival

The paper shows that spermatogonia differentiation triggers somatic support cells to form septate junctions, essential for germ cell survival in Drosophila.

A Developmental Mechanism to Regulate Alterna6ve Polyadenyla6on in an Adult Stem Cell Lineage

The paper identifies a developmental mechanism involving PCF11 and Cbc in Drosophila spermatogenesis that regulates alternative polyadenylation site usage during differentiation.

A cell-type-specific multi-protein complex regulates expression of Cyclin B protein in Drosophila male meiotic prophase

The paper shows that Lut and Syp, along with Rbp4 and Fest, regulate Cyclin B expression timing during Drosophila male meiotic prophase.

Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage

The paper identifies developmentally regulated alternative 3' end cleavage of transcripts in Drosophila spermatogenesis, showing how it affects protein expression during differentiation.

miR-9a regulates levels of both rhomboid mRNA and protein in the early Drosophila melanogaster embryo

This study shows that miR-9a regulates rhomboid mRNA and protein levels in Drosophila embryos by promoting mRNA degradation and inhibiting translation.

Single cell visualisation of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development

The paper visualizes the co-expression of mir-9a and Senseless during Drosophila PNS development, revealing dynamic regulatory relationships that differ between embryonic and larval stages.