Author

Gerd P. Pfeifer

Van Andel InstituteORCID 0000-0002-5080-9604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Assay:DNA methylation· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Assay:Hi-C· 2 Research Focus:variant calling· 2

Frequent Co-Authors

Wei CuiiD· 3 shared Zhijun HuangiD· 3 shared Adam KlaissiD· 1 shared Chun-Wei David CheniD· 1 shared Dean PettingaiD· 1 shared Fan FengiD· 1 shared Haley GoreiD· 1 shared Ishara S. RatnayakeiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersGenomics

Wei CuiORCID

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Author profile →

5 papers

Recent·Most cited

SMCHD1 loss re-wires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells

Zhijun Huang, Wei Cui, Adam Klaiss, Gerd P. Pfeifer

This study shows that SMCHD1 loss disrupts enhancer organization and chromatin accessibility in muscle cells, leading to altered MYOD1 regulation and potential FSHD pathology.

bioRxiv · Feb 22, 2026 · PreprintMolecular Biology

DNA methylation landscapes in human cells and their chromatin determinants

Wei Cui, Zhijun Huang, Gerd P. Pfeifer

The paper investigates DNA methylation patterns in human bronchial epithelial cells and identifies chromatin determinants that influence their establishment.

Ageing and Cancer Research & Treatment · Dec 18, 2025Peer-reviewedGenomics

SMCHD1 maintains heterochromatin and genome compartments in human myoblasts

Zhijun Huang, Wei Cui, Ishara S. Ratnayake, Rabi Tawil, Gerd P. Pfeifer

This study shows SMCHD1 maintains heterochromatin and genome compartments in human myoblasts by anchoring heterochromatin domains and preventing epigenome modification.

bioRxiv · Jul 7, 2024 · PreprintGenomics

Mapping of DNA damage genome-wide at nucleotide resolution by circle-damage-sequencing

Seung‐Gi Jin, Dean Pettinga, Jennifer S. Johnson, Gerd P. Pfeifer

This paper introduces circle-damage-seq, a method to map DNA damage at nucleotide resolution genome-wide, demonstrating its application to UVB-induced CPDs and 4-hydroxynonenal-induced adducts.

bioRxiv · Jun 28, 2020 · PreprintGenomics

Three-dimensional regulation of HOXA cluster genes by a cis-element in hematopoietic stem cell and leukemia.

Xue Qing David Wang, Haley Gore, Pamela Himadewi, Fan Feng, Lu Yang, Wanding Zhou, Yushuai Liu, Xinyu Wang, Chun-Wei David Chen, Jianzhong Su, Jie Liu, Gerd P. Pfeifer, Xiaotian Zhang

The paper investigates how 3D chromatin interactions regulate HOXA cluster genes in HSCs and leukemia by analyzing the role of the Geneless Canyon region.

bioRxiv · Apr 16, 2020 · PreprintGenomics