Wei Cui

This study shows that SMCHD1 loss disrupts enhancer organization and chromatin accessibility in muscle cells, leading to altered MYOD1 regulation and potential FSHD pathology.

The paper investigates DNA methylation patterns in human bronchial epithelial cells and identifies chromatin determinants that influence their establishment.

This study shows SMCHD1 maintains heterochromatin and genome compartments in human myoblasts by anchoring heterochromatin domains and preventing epigenome modification.

The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.