Mauricio Torres

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

This study shows that neuronal SEL1L-HRD1 ERAD is critical for one-carbon metabolism, motor function, and survival, with loss leading to severe neurological defects.

This study reveals a synergy between SEL1L-HRD1 ERAD and autophagy in maintaining mitochondrial structure and thermogenic capacity in brown adipocytes.

This study shows that SEL1L-HRD1 ERAD is essential for Purkinje cell function and causes progressive cerebellar ataxia in mice.