Rainer Spanagel

The paper evaluates multi-laboratory studies to identify promising treatments by assessing effect sizes and experimental rigor across different medical fields.

This study identifies DNA methylation changes in AUD patients after psilocybin treatment, finding significant CpG sites and methylation patterns linked to neuroplasticity and immune functions.

The paper identifies a transdiagnostic brain functional connectivity signature of craving across substance use disorders using connectome-based predictive modeling.

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

This study identifies a thalamo-amgydalar circuit dysfunction caused by early-life adversity that contributes to chronic pain and anxiety in female mice.

This study performs a cross-species meta-analysis of transcriptomic data from AUD patients and animal models to identify common differentially expressed genes and pathways involved in AUD.

This study investigates sex and age differences in addiction and compulsive-like drinking behavior in rats using an alcohol deprivation effect model.

This study shows that alcohol-dependent rats show increased habitual behavior towards a sweet reward in two tasks, and DMS inactivation in non-dependent rats also increases habitual behavior.

The paper identifies acute and lasting molecular, cellular, and behavioral changes in mice after single-dose ethanol intoxication using proteomics and imaging.

This study shows that adolescent restraint stress in rats leads to long-term spinal neuron sensitization, which is further enhanced by a mild-nociceptive input in adulthood.

This study finds female mice show stronger addictive-like behaviors to sugar compared to males in multiple tests, suggesting sex differences in sugar addiction.

The paper shows that extinction learning involves coordinated population-wide neural transitions in the mPFC, not suppressed responses to conditioned stimuli.

This study shows that adolescent peer-rejection in rats leads to lasting sex-dependent changes in alcohol-seeking behavior, with females showing increased reinstatement and males decreased reinstatement.

This study identifies a common molecular mechanism involving mGluR2 dysfunction linking cognitive deficits and alcohol craving, and develops a biomarker for targeted interventions.