Author

Sabrina M. Leddy

Leibniz Institute of Virology (LIV)ORCID 0000-0002-5104-3866Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Martin V. Hamann· 3 shared Cédric FeschotteiD· 2 shared Maisha AdibaiD· 2 shared Ulrike C. LangeiD· 2 shared Adam T. GrundhoffiD· 1 shared Carola Schneider· 1 shared Christoph Schwarz· 1 shared Daniel Foth· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Martin V. Hamann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular BiologyHuman Gene TherapyPeer-reviewedSep 16, 2026

Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy

Hendrik Jahnz, Martin V. Hamann, H.O. Kim…·Ulrike C. Lange

This paper develops a CD7-targeted rAAV vector for efficient gene delivery to human T and NK cells, showing reduced off-target effects and improved transgene expression through genome optimization.

DOI 10.1177/10430342261487919

humanexperimental assay

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MicrobiologybioRxivPreprintSep 22, 2025

Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses

Martin V. Hamann, Lisa Brauckmann, Christoph Schwarz…·U. Schiefer Lange

This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.

DOI 10.1101/2025.09.22.676989

humanbulk RNA-seq

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Cancer BiologyActa Neuropathologica CommunicationsPeer-reviewedJul 22, 2025

Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes

Martin V. Hamann, Shweta Godbole, Maisha Adiba…·Julia E. Neumann

This study identifies distinct TE transcription profiles in ATRT subtypes, revealing unique patterns in ATRT-MYC that may inform new therapeutic strategies.

1 citation

humanbulk RNA-seq

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ImmunologyGenome biologyPeer-reviewedFeb 23, 2025

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers

Manvendra Singh, Sabrina M. Leddy, L. Iñiguez…·Cédric Feschotte

This study investigates the role of transposable elements in HIV-1 elite controllers, finding distinct transcriptomic profiles and differential TE expression associated with antiviral resistance.

16 citationstop 4%

humanbulk RNA-seq

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