Stéphane Descorps‐Declère

This study shows that the E. coli CNF1 toxin reprograms intestinal stem cells in organoids to a fetal-like state, inducing a serrated colorectal cancer transcriptional signature.

The paper examines CoV prevalence in bats from Yunnan Province, identifying new SARSr-CoVs and factors influencing their distribution and zoonotic risk.

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

The paper investigates the functional roles of megasatellites in yeast adhesion and flocculation by deleting genes and evolving strains.

The paper evaluates the efficacy of CRISPR-Cas nucleases on microsatellites linked to human disorders, identifying variations in cleavage efficiency and off-target mutations.

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.

The paper identifies over 16,000 secreted proteins in Legionella species, revealing their ability to acquire eukaryotic-like genes for intracellular replication in human cells.

The paper redesigns a genomic region for improved Hi-C analysis, revealing insights into homolog pairing and loop formation during meiosis.