Diphenyleneiodonium chloride inhibits MYCN-amplified neuroblastoma by targeting MYCN induced mitochondrial alterations
Soraya Epp, Stephanie Maher, Amirah Adlina Abdul Aziz, Simone Marcone, Donagh Egan, Saija M. Haapa-Paananen, Vidal Fey, Kristiina Iljin, Kieran J. Wynne, Lasse D. Jensen, Walter Kölch, Melinda Halász
This study identifies diphenyleneiodonium chloride as a compound that targets MYCN-amplified neuroblastoma by inducing proteasomal degradation of MYCN and reversing mitochondrial alterations.
bioRxiv · Oct 20, 2024 · PreprintCancer Biology