The paper shows that balancing viral damage, immune response, and tissue repair can prevent death from lethal influenza by combining antiviral drugs with strategies to enhance epithelial repair.

Science · Nov 20, 2025Peer-reviewedImmunology

Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy

Abdul Ahad, Feng Leng, Hiroshi Ichise, Edward C. Schrom, Jae Young So, Carter Sellner, Yang Gu, Wenjuan Wang, Kieu C. Do, Woo Yong Park, Rachel Yang, Karen Wolcott, Ferenc Livák, Michael J. Kruhlak, Olga N. Aprelikova, , Yang Li

This study identifies immune-tumor interactions that drive tumor dormancy in a mouse model, highlighting IFN-γ-KLF4-SLURP1 and CD200-CD200R1 pathways.

bioRxiv · Apr 16, 2025 · PreprintCancer Biology

Spatial Patterning Analysis of Cellular Ensembles (SPACE) discovers complex spatial organization at the cell and tissue levels

Edward C. Schrom, Erin McCaffrey, Vivek Sreejithkumar, Andrea J. Radtke, Hiroshi Ichise, Armando Arroyo-Mejías, Emily E. Speranza, Leanne Arakkal, Nishant Thakur, Spencer M. Grant, Ronald N. Germain

SPACE identifies complex spatial patterns in high-plex spatial data by analyzing ensembles of tissue elements across multiple datasets.

bioRxiv · Dec 8, 2023 · PreprintBioinformatics