ImmunologybioRxivPreprint
Dose-dependent activation of Syk and SHIP1 by LynA and LynB at steady state creates a threshold for macrophage signaling in the absence of receptor engagement
S. Erandika Senevirathne, Carter Sellner, Silvia Toledo Ramos, Tanya S. Freedman
The paper shows that LynA and LynB expression levels determine steady-state phosphorylation of Syk and SHIP1, limiting macrophage signaling without microbial stimulation.
DOI 10.64898/2026.02.25.708040