This study identifies PD-1's role in maintaining stem-like CD8+ T cells through TCR affinity regulation and signaling fine-tuning, showing its impact on immunotherapy efficacy.

Nature · Nov 26, 2025Peer-reviewedImmunology

Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML

Gege Gui, Molly A. Bingham, Julius R. Herzog, Abigail Wong-Rolle, Laura Williams Dillon, Meghali Goswami, Eddie Martin, Jason Reeves, Sean T. Kim, Arya J. Bahrami, Hermann Franz Degenhardt, George Zaki, Prajan Divakar, Edward C. Schrom, Katherine R. Calvo, , Chen Ning Zhao

CosMx spatial transcriptomics of bone marrow from 6 refractory/relapsed AML patients shows CD14+ monocytes rising in leukemia-cell neighborhoods after pembrolizumab in responders, dendritic cells in nonresponders.

Science Advances · Jul 9, 2025Peer-reviewedCancer Biology✦ In-depth digest

Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy

Abdul Ahad, Feng Leng, Hiroshi Ichise, Edward C. Schrom, Jae Young So, Carter Sellner, Yang Gu, Wenjuan Wang, Kieu C. Do, Woo Yong Park, Rachel Yang, Karen Wolcott, Ferenc Livák, Michael J. Kruhlak, Olga N. Aprelikova, , Yang Li

This study identifies immune-tumor interactions that drive tumor dormancy in a mouse model, highlighting IFN-γ-KLF4-SLURP1 and CD200-CD200R1 pathways.

bioRxiv · Apr 16, 2025 · PreprintCancer Biology

Spatial Patterning Analysis of Cellular Ensembles (SPACE) discovers complex spatial organization at the cell and tissue levels

Edward C. Schrom, Erin McCaffrey, Vivek Sreejithkumar, Andrea J. Radtke, Hiroshi Ichise, Armando Arroyo-Mejías, Emily E. Speranza, Leanne Arakkal, Nishant Thakur, Spencer M. Grant, Ronald N. Germain

SPACE identifies complex spatial patterns in high-plex spatial data by analyzing ensembles of tissue elements across multiple datasets.

bioRxiv · Dec 8, 2023 · PreprintBioinformatics