Suganya Sivagurunathan

Syntaxin-3 regulates Tight Junction Assembly in Human Retinal Pigment Epithelium

This study identifies STX3 in human RPE cells and shows its role in tight junction assembly, challenging previous assumptions about its absence and functional compensation by STX1A.

Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D

This study shows that vimentin expression in breast cancer cells changes 3D cluster morphology, enhances migration, and increases cell-matrix interactions.

Alternate dyes for image-based profiling assays

This study evaluates alternative dyes for image-based profiling assays, finding that some substitutions maintain performance while enabling live-cell imaging and expanded feature space.

A versatile information retrieval framework for evaluating profile strength and similarity

The paper introduces a statistical framework using mean average precision (mAP) to evaluate phenotypic activity and consistency in high-dimensional profiling data across various modalities and perturbation types.

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

A Postdoctoral Training Program in Bioimage Analysis

This paper describes a postdoctoral training program in bioimage analysis, highlighting its components, outcomes, and implications for training experts in professional skills.

In silico analysis of piRNAs in retina reveals potential targets in intracellular transport and retinal degeneration

The paper identifies piRNAs in human retina and RPE using RNA-seq, showing their role in intracellular transport, circadian rhythms, and retinal degeneration.