Megan N. Michalski

This study shows that deleting Znrf3 in osteoblasts reduces trabecular bone mass and alters cortical bone structure, while Rnf43 deletion has minimal effects.

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

This paper models a human FZD2 variant in mice, identifies limb and cleft palate phenotypes, and shows DKK1 inhibition can normalize limb defects.