Valentin I. Borshchevskiy

The paper determines the Cryo-EM structure of a dodecameric double-ferritin-fold protein from an Asgard archaeon, revealing its unique structural features and implications for iron metabolism.

This study provides structural insights into human recoverin, revealing its unique calcium and zinc interactions compared to bovine recoverin.

This study uses ABEL-FRET to measure structural dynamics of A2A adenosine receptors across timescales, showing agonists shift receptor states and accelerate conformational exchange.

The paper investigates the interaction of rifampicin and related compounds with CYP143 in M. tuberculosis, revealing binding modes and structural insights into resistance mechanisms.

The paper identifies a conserved carotenoid-binding site in heliorhodopsins, revealing their role in light harvesting through exogenous xanthophyll recruitment due to inverted membrane topology.

The paper identifies and characterizes double ferritin-like proteins (DFLPs) that form homodimers, bind heme, and exhibit ferroxidase activity, with some targeted to encapsulin shells.

The paper characterizes CryoRhodopsins from cold environments, revealing their dual functionality and structural adaptations to low temperatures.

The paper discovers a flavin-based fluorescent protein, LSSFbFP, with a large Stokes shift, achieved through excited state proton transfer, and validates its mechanism using spectroscopy and crystallography.

This paper describes the engineering of soluble bacteriorhodopsin analogues and reports their crystal structure, demonstrating the potential of protein engineering for developing molecular tools.