Yukihiro Akeda

A universal plug-and-display vaccine platform for mucosal and systemic immunity using Bacillus subtilis membrane vesicles

This paper develops a universal vaccine platform using Bacillus subtilis membrane vesicles that elicit both systemic and mucosal immunity against Yersinia pestis.

Genome-scale dissection of phase-variable gene function in Campylobacter jejuni using a stabilized phasotype library

This paper introduces PV-GenShift, a platform to stabilize phase-variable gene expression in C. jejuni, identifying phasotypes linked to serum resistance and mouse colonization.

Periodontal pathogen-derived extracellular vesicles promote EGFR-dependent malignant traits in human pancreatic cancer cells

This study shows that extracellular vesicles from Aggregatibacter actinomycetemcomitans promote malignant traits in human pancreatic cancer cells via EGFR-ERK/Akt signaling.

Nutrient Acquisition Drives Edwardsiella tarda Pathogenesis in Necrotizing Soft Tissue Infection

This study identifies nutrient acquisition genes critical for Edwardsiella tarda survival in NSTI using TraDIS, showing metabolic adaptation drives pathogenesis.

Oligomeric coiled-coil adhesins that drive chain-like adhesion diversify surface colonization strategies in Shiga toxin-producing Escherichia coli

This study investigates CLAP in LEE-negative STEC, showing chain formation dynamics and genetic diversity, with claB prevalence and EibG's role in virulence.